FORMULATION AND EVALUATION OF ASPIRIN-LOADED PLGA NANOPARTICLES FOR OPHTHALMIC USE

ANIL PETHE; ARYA SHANBHAG; ATUL SHERJE; SURENDRA AGRAWAL

doi:10.22159/ijap.2023v15i2.46636

Authors

ANIL PETHE Datta Meghe College of Pharmacy, Datta Meghe Institute Higher Education and Research (DU), Wardha https://orcid.org/0000-0002-6380-1847
ARYA SHANBHAG Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’S NMIMS, Mumbai
ATUL SHERJE Bhanuben Nanavati College of Pharmacy, SVKM, Mumbai 400056
SURENDRA AGRAWAL Datta Meghe College of Pharmacy, Datta Meghe Institute Higher Education and Research (DU), Wardha https://orcid.org/0000-0002-1149-5307

DOI:

https://doi.org/10.22159/ijap.2023v15i2.46636

Keywords:

Nanoparticles, Ocular, Aspirin, PLGA, Eye diseases

Abstract

Objective: The objective of this work was to increase the bioavailability of Aspirin to the retina by increasing its bioavailability to blood. This was achieved by forming aspirin-loaded PLGA nanoparticles

Methods: Aspirin-loaded PLGA nanoparticles were prepared by a solvent evaporation process. The PLGA was dissolved in the proper solvent and added dropwise to the Aspirin-albumin solution revolving at 3000 rpm. Glutaraldehyde was used as a cross-linker at 20% concentration. The nanoparticles were obtained after passing the solution through HPH and subsequent centrifugation.

Results: The prepared nanoparticles were found to be spherical with the smooth surface as seen in SEM. and with a size of 160.9 nm. Aspirin-loaded PLGA nanoparticles showed in vitro drug release of 71.4 % and ex-vivo permeation of 66.2 %. The formulation was found to be stable for six months.

Conclusion: The developed aspirin-loaded polymeric nanoparticles could be effective for the controlled delivery of aspirin in the early prevention of diabetic retinopathy.

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