AN OVERVIEW: DEVELOPMENT OF COLON DRUG DELIVERY SYSTEM AND ITS APPLICATION AND LIMITATIONS

IYAN SOPYAN; ANITA DEWI PERMATASARI KOMARUDIN; JESSICA ANLIANI HUANG; INSAN SUNAN K. S.

doi:10.22159/ijap.2023v15i1.46681

Authors

IYAN SOPYAN Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia. Jl. Raya Bandung Sumedang KM.21, Jatinangor, 45363, Study Center of Dosage Form Development, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia Jl. Raya Bandung-Sumedang KM.21, Jatinangor, 45363 https://orcid.org/0000-0001-7616-5176
ANITA DEWI PERMATASARI KOMARUDIN Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia. Jl. Raya Bandung Sumedang KM.21, Jatinangor, 45363
JESSICA ANLIANI HUANG Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia. Jl. Raya Bandung Sumedang KM.21, Jatinangor, 45363 https://orcid.org/0000-0003-3659-5774
INSAN SUNAN K. S. Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia. Jl. Raya Bandung Sumedang KM.21, Jatinangor, 45363 https://orcid.org/0000-0001-7616-5176

DOI:

https://doi.org/10.22159/ijap.2023v15i1.46681

Keywords:

Colon drug delivery system, Colon cancer, Nanoparticles, Colon targeted drug delivery

Abstract

There are various routes of drug administration. Oral administration is considered the most preferred route in drug administration for systemic effects, but the oral administration is not suitable for people with ulcerative colitis, crohn's disease, bowel cancer, diarrhea, treatment of diseases that sensitive to circadian rhythms such as asthma and angina, as well as for steroids administration. The delivery of targeted drugs has the goal of achieving the desired therapeutic profile by delivering the drug to the target site. This study conducted by reviewing related articles based on specify keywords on Science Direct database that has been published for the last 10 y. In recent decades, research has been conducted to develop methods that can target drugs to specific organs. The focusing on targeted drug delivery system to the colon, the various ways that were carried out for its approach, as well as the evaluation. By this study, some challenges in the colon drug delivery system could be overcome along with new approaches.

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