THE EFFECT OF HANDING MERCURY DROP ELECTRODE ON DIFFERENTIAL PULSE POLAROGRAPHIC BEHAVIOR AND DETERMINATION OF ROSUVASTATIN IN PURE AND PHARMACEUTICAL TABLETS

Authors

  • Abdul Azizs Ramadan Aleppo University
  • Hasna Mandil Aleppo University
  • Nour Ghazal Aleppo University

Keywords:

Differential pulse polarographic method, Handing mercury drop electrode, Rosuvastatin, Pharmaceutical tablets

Abstract

Objective: Developing a simple, accurate and very sensitive differential pulse polarographic method (DPPM) for determination of rosuvastatin (RSV) in pure and tablets dosage forms using handing mercury drop electrode (HMDE).

Methods: The DPPM was applied in Na2HPO4 buffer at pH 1.5 using a HMDE in optimal conditions.

Results: One redaction peak was observed in the range -929 to -940 mV (Ep). The peak current Ip is linear over the ranges 0.9631-192.61 ng. mL-1; Which led to increase the sensitivity about ten and hundred times when using SMDE and DME, respectively. The relative standard deviation did not exceed 3.6% and regression analysis showed a good correlation coefficient (R2= 0.9998). The limit of detection (LOD) and the limit of quantification (LOQ) were to be 0.112 and 0.34 ng. mL-1, respectively. The amounts of RSV in different tablet dosage forms were decreases with the time (1.1-1.7% after six months at the end of the validity period).

Conclusion: The proposed method was successfully applied to determine very small amounts of RSV (0.9631 ng. mL-1) in pure form and in pharmaceutical tablets.

 

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References

Mori Y, Kuriyama G, Tanaka T, Tajima N. Usefulness of aggressive lipid-lowering therapy with rosuvastatin in hypercholesterolemic patients. Endocrine 2009;36(3):412-8.

Nissen S, Nicholls S, Sipahi I, Libby P, Raichlen JS, Ballantyne CM. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis. Asteroid Trial JAMA 2006;295(13):1556-65.

Lennernas H, Fager G. Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Clin Pharmacokinet 1997;32:403-25.

Jones PH, Davidson MH, Stein EA, Bays HE, McKenney JM, Miller E. Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses. Am J Cardiol 2003;92(2):152-1604.

Mehta TN, Patel AK, Kulkarni GM, Suubbaiah G. Determination of rosuvastatin in the presence of its degradation products by a stability indicating LC method. JAOAC Int 2005;88(4):1142-47.

Beludari MI, Prakash KV, Mohan GK. RP-HPLC method for simultaneous estimation of rosuvastatin and ezetimibe from their combination tablet dosage form. Int J Chem Analyt Sci 2013;4(4):205-9.

Kaila HO, Ambasana MA, Thakkar RS, Saravaia HT, Shah AK. A new improved RP-HPLC method for assay of rosuvastatin calcium in tablets. Indian J Pharm Sci 2010;72(5):592–98.

Suslu I, Celebier M, Altnoz S. Determination of rosuvastatin in pharmaceutical formulations by capillary zone electrophoresis. Chromatographia 2007;66:65-72.

Uyar B, Celebier M, Altinoz S. Spectrophotometric determination of rosuvastatin calcium in tablets. Pharm 2007;62:411-13.

Afroz A, Haque T, Uddin Talukder MdM, Ashraful Islam SM. spectrophotometric estimation of rosuvastatin calcium and glimepiride in tablet dosage form. Asian J Pharm Anal 2011;1(4):74-8.

Ergin G, Caglar S, Onal A, Erturk toker S, Spectrophotometric determination of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors in pharmaceutical preparations. Turkish J Chem 2013;37:171-81.

Ramadan AA, Mandil H, Alshelhawi N. Spectrophotometric determination of rosuvastatin calcium in pure form and pharmaceutical formulations by the oxidation using iodine and formation triiodide complex in acetonitrile. Int J Pharm Pharm Sci 2014;6(5):579-85.

Sacide A, Banu U. Electrochemical behaviour and voltammetric determination of rosuvastatin calcium in pharmaceutical preparations using a square-wave voltammetric method. Anal Methods 2013;5(20):5709-16.

Ramadan AA, Mandil H, Ghazal N. Electrochemical behavior and differential pulse polarographic determination of rosuvastatin in pure form and in pharmaceutical preparations using dropping mercury electrode. Int J Pharm Pharm Sci 2014;6(3):128-33.

Ramadan AA, Mandil H, Ghazal N. Differential pulse polarographic behavior and determination of rosuvastatin in pure form and in pharmaceutical preparations using a static mercury drop electrode. Int J Pharm Pharm Sci 2015;7(1):389-96.

Ramadan AA, Mandil H, Hafez B. Differential pulse polarography of atorvastatin in pure and pharmaceutical dosage forms using static mercury drop electrode. Int J Pharm Pharm Sci 2013;5(1):434-40.

Ramadan AA, Mandil H, Hafez B. Differential pulse polarographic determination of atorvastatin in pharmaceutical dosage forms using dropping mercury electrode. Asian J Chem 2013;25(6):3467-72.

Ramadan AA, Mandil H, Hafez B. Effect of hanging mercury drop electrode on differential pulse polarographic analysis of atorvastatin in pharmaceuticals using borax buffer at pH7.50. Int J Pharm Pharm Sci 2012;4(Suppl 5):540-6.

Ramadan AA, Mandil H. Determination of gatifloxacin in pure form and pharmaceutical formulations by differential pulse polarographic analysis. Anal Biochem 2010;404:1-7.

Ramadan AA, Mandil H, Genco T. Determination of carbinoxamine maleate in pharmaceuticals by direct and differential pulse polarography. Asian J Chem 2009;21(9):7387-97.

Ramadan AA, Mandil H, Hafez B. Determination of dipyrone in pure form and pharmaceutical formulations by differential pulse polarographic analysis. Asian J Chem 2011;21(1):403-06.

Ramadan AA, Mandil H. Determination of lomefloxacin in pharmaceuticals using differential pulse polarographic analysis. Int J Pharm Pharm Sci 2012;4(Suppl 5):255-61.

Published

01-03-2015

How to Cite

Ramadan, A. A., H. Mandil, and N. Ghazal. “THE EFFECT OF HANDING MERCURY DROP ELECTRODE ON DIFFERENTIAL PULSE POLAROGRAPHIC BEHAVIOR AND DETERMINATION OF ROSUVASTATIN IN PURE AND PHARMACEUTICAL TABLETS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 3, Mar. 2015, pp. 300-7, https://mail.innovareacademics.in/journals/index.php/ijpps/article/view/4509.

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