ANTIPYRETIC EFFECTS OF QURANI PLANTS' MIXTURE (A NEW PHARMACEUTICAL PRODUCT)
Keywords:
Antipyretic effect, Edible and medicinal plants, Nil, Histopathological studiesAbstract
Objective: QURANI plants' mixture is a new pharmaceutical product composed of some edible and medicinal plants (15 plants) mentioned in the Holy Quran (in a certain percentage, according to that is mentioned in Patent no. 1429/2013, presented to the Academy of Scientific Research and Technology, Egypt in 11/9/2013). The main aim of this work is to determine antipyretic effects of this new mixture and to study side effects of this mixture on many important organs of the body, if present.
Methods: In vivo studies of antipyretic effects of feeding adult female albino rats under investigation with 2, 4 and 8 g/kg of QURANI plants' mixture was carried out after 0, 1, 2, 3 and 24 hours of the induction of fever by yeast extract. Important organs' (Heart, Brain, Kidney, Liver, Lung, Spleen, Stomach and Colon) weights were checked, in addition to the investigation of their histopathological structures, in order to check any bad side effects of this new pharmaceutical product.
Results: In vivo studies of the antipyretic effect of feeding adult female albino rats under investigation with 2, 4 and 8 g/kg of QURANI plants' mixture showed that, the bodies' temperatures degrees of investigated rats were decreased till reaching to 37о C in case of feeding these rats with all investigated doses of QURANI plants' mixture. The highest antipyretic effect was obtained by feeding rats with 8 g/kg of QURANI plants' mixture. Based on weights' estimation and histopathological investigations, it was found that, all investigated doses (2, 4 and 8 g/kg) of QURANI plants' mixture have not any bad side effects on many important organs (Heart, Brain, Kidney, Liver, Lung, Spleen, Stomach and Colon) of all examined rats.
Conclusion: Results of the antipyretic effect of QURANI plants' mixture will lead us to more biological and chemical investigations of this new, cheap and safe pharmaceutical natural product.
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References
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