DURIAN SEED UTILIZATION AS A BASE MATERIAL OF TOPICAL GEL

Nilsya Febrika Zebua; Effendy De Lux Putra; Urip Harahap; Jamaran Kaban

doi:10.22159/ajpcr.2018.v11s1.26600

Authors

Nilsya Febrika Zebua Department of Faculty of Pharmacy, Universitas Sumatera Utara, North Sumatera, Indonesia
Effendy De Lux Putra Department of Faculty of Pharmacy, Universitas Sumatera Utara, North Sumatera, Indonesia
Urip Harahap Department of Faculty of Pharmacy, Universitas Sumatera Utara, North Sumatera, Indonesia
Jamaran Kaban Department of Faculty of Mathematics and Science, Universitas Sumatera Utara, North Sumatera, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s1.26600

Keywords:

Gel, Gum, Durian seed, Topical drug delivery

Abstract

Â Objective: This research is aimed to investigate that durian seed gum is potential as an excipient in topical drug delivery. Durian seed gum is isolated from low-cost source and usually discarded.

Methods: A certain amount of durian seed gum was isolated and characterized by scanning electron microscopy energy dispersive X-ray (SEM-EDX) and infrared spectrophotometer. The isolation method is divided into centrifuge and heating method, and the results of both methods are compared in their ability to form a gel and their evaluation.

Results: The infrared spectra of durian seed gum by centrifugal method indicate the presence of -OH, -COOH, -CH groups, and the addition of C=O and ester groups on the heating method, i.e., at wave number 1726.22 cmâˆ’1. SEM-EDX shows the form of hollow surface particles, and the elements contained are C, O, K, Cl, and Mg. Durian seed gum of both methods formed a gel with boiling water at a concentration of 5% giving transparent and non-flowing results.

Conclusion: Durian seed gum by the heating method is a low-methoxyl pectin compound because it is extracted at an alkaline pH. Durian seed gum can form a gel and complete the gel evaluation requirements.

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