CURCUMIN MICROENCAPSULATION USING CHITOSAN–ETHYL CELLULOSE–GMS MIXTURE FOR PRESERVATION OF MUCOADHESIVE PROPERTIES AND CONTROLLED RELEASE KINETIC

DENI RAHMAT; YUNAHARA FARIDA; NOVI YANTIH; GITA SEPTYANA DEWI; SARAH ANGELA PURNAMA

doi:10.22159/ijap.2022v14i1.42899

Authors

DENI RAHMAT Faculty of Pharmacy, Pancasila University, Srengseng Sawah, Jagakarsa, Jakarta Selatan 12640, Indonesia https://orcid.org/0000-0003-1261-0669
YUNAHARA FARIDA Faculty of Pharmacy, Pancasila University, Srengseng Sawah, Jagakarsa, Jakarta Selatan 12640, Indonesia
NOVI YANTIH Faculty of Pharmacy, Pancasila University, Srengseng Sawah, Jagakarsa, Jakarta Selatan 12640, Indonesia
GITA SEPTYANA DEWI Faculty of Pharmacy, Pancasila University, Srengseng Sawah, Jagakarsa, Jakarta Selatan 12640, Indonesia
SARAH ANGELA PURNAMA Faculty of Pharmacy, Pancasila University, Srengseng Sawah, Jagakarsa, Jakarta Selatan 12640, Indonesia

DOI:

https://doi.org/10.22159/ijap.2022v14i1.42899

Keywords:

Curcumin, Microencapsulation, Mucoadhesive, Release

Abstract

Objective: This research aimed to prepare curcumin microcapsules by the spray drying method and to evaluate their characteristics.

Methods: The microcapsules were prepared by the spray drying method. The generated microcapsules were evaluated for organoleptic, morphology, particle size, the percentage of curcumin and water content. Furthermore, the release of curcumin from the microcapsules was tested in vitro and compared to uncoated curcumin powder. In addition, the mucoadhesive properties of uncoated curcumin powder and curcumin microcapsules were also evaluated.

Results: The results showed that the microcapsules had spherical shape with particle size in the range of 100–1009 µm and water content of 9.34% (w/w) (FIII) and 8.09% (w/w) (FVI). The release of curcumin from its uncoated powder and the microcapsules FVI within 8 h were 8.87% and 26.32% (w/w), respectively. It was found that the mucoadhesive properties of microcapsules FVI were better than those of FIII and uncoated curcumin powder. Microcapsules FVI rendered the cumulative amount of curcumin remaining on the intestinal mucosa of 55% (w/w) within 3 h.

Conclusion: Accordingly, curcumin microcapsules generated by spray drying could be further formulated into various solid dosage forms for a better therapeutic effect.

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